Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection : a composite of redistribution and proliferation

authors	Pakker, N.G.; Notermans, D.W.; Boer, R.J. de; Roos, M.T.; Wolf, F. de; Hill, A.; Leonard, J.M.; Danner, S.A.; Miedema, F.; Schellekens, P.Th.A.
source	Nature medicine, Volume: 4, Issue: 2 (1998), pp. 208-214
full text	[Full text]
publisher	Nature Publishing Group
URL publisher	[Website publisher]
document type	Article
disciplines	Biologie
abstract	The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.
ISSN	1078-8956