|Microbial agents, allergens and atopic diseases - contributions to the PARSIFAL study
Microbial agents, allergens and atopic diseases - contributions to the PARSIFAL study / Hendrikje Everdina Schram-Bijkerk - [S.l.] : [s.n.], 2006 - Tekst. - Proefschrift Universiteit Utrecht
Trefwoorden: allergy, asthma, hygiene hypothesis, farm, anthroposophic lifestyle, dust, microbial agents, endotoxin, allergens, moulds
Over the past decades, the prevalence of allergic diseases in childhood has increased considerably, especially in many western industrialized countries. The rising prevalence might be due to changes in allergen exposure, early infections and/or lifestyle factors. The PARSIFAL (Prevention of Allergy - Risk factors for Sensitization In children related to Farming and Anthroposophic Lifestyle) project focused on two groups of children who have shown a relatively low prevalence of atopic diseases and sensitization: farm children and children of families with an anthroposophic lifestyle. Contact with farm animals has been associated with a decrease in the risk of atopic disease, which might be due to exposure to microbial compounds. The anthroposophic way of life involves several characteristics, such as restrictive use of antibiotics, antipyretics and vaccinations, as well as certain dietary habits, which might be negatively associated with atopic diseases.