| authors | Matos, A.J.; Lopes, C.; Carvalheira, J.; Santos, M.; Rutteman, G.R.; Gartner, F. |
| source | Journal of Comparative Pathology, Volume: 134 (2006), pp. 182-189 |
| full text | [Full text]
|
| document type | Article |
| disciplines | Diergeneeskunde |
| abstract | The relationship between E-cadherin epithelial expression, as detected by immunohistochemical
methods, and other clinico-pathological characteristics of canine malignant mammary tumours was
studied in 77 tumours surgically removed from 45 female dogs. The immunohistochemical assessment
was based on the estimated percentage of epithelial cells with membranous labelling. Reduction of
E-cadherin expression was significantly related to size and ulceration of tumours but not to fixation to skin
or underlying tissue; it was also related to lymph node metastasis, necrosis and infiltrative growth.
Histological type (but not histological grade) was related to E-cadherin expression, with solid tumours
more frequently lacking expression and tubulopapillary tumours showing increased expression as
compared with the other types. The significant relationship between E-cadherin and other known factors
of poor prognosis suggests that the loss of E-cadherin expression may have prognostic value in canine malignant mammary tumours. |
| ISSN | 0021-9975 |
